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Sciences indexed since 1998 submit story | join | login   view all biology business chemistry engineering geography health mathematics society   all     idiopathic systemic capillary leak syndrome (clarkson's disease): the mayo clinic experience submitted by soteshkappalo 2 years and 1 month ago to determine clinical features, natural history, and outcome of a well-defined cohort of 25 consecutive patients with idiopathic systemic capillary leak syndrome (scls) evaluated at a tertiary care center. Patients and records of patients diagnosed as having scls from november 1, 1981, through april 3, 28, were reviewed. Descriptive statistics were used to analyze patient demographics, clinical features, complications, and therapeutic interventions. Of the 34 patients whose records were reviewed, 25 fulfilled all diagnostic criteria for scls. The median age at diagnosis of scls was 44 years. Median follow-up of surviving patients was 4. 9 years, and median time to diagnosis from symptom onset was 1. 1 years (interquartile range,. 5-4. 1 years). generic viagra online buy generic viagra cheap generic viagra cheap generic viagra buy generic viagra buy cheap viagra cheapest viagra viagra without a doctor prescription cheap generic viagra Flulike illness or myalgia was reported by 14 patients (56%) at onset of an acute attack of scls, and rhabdomyolysis developed in 9 patients (36%). Patients with a greater decrease in albumin level had a higher likelihood of developing rhabdomyolysis (p=. 3). Monoclonal gammopathy, predominantly of the igg- type, was found in 19 patients (76%). The progression rate to multiple myeloma was. 7% per person-year of follow-up. The overall response rate to the different therapies was 76%, and 24% of patients sustained durable (>2 years) complete remission. The estimated 5-year overall survival rate was 76% (95% confidence interval, 59%-97%). Systemic capillary leak syndrome, a rare disease that occurs in those of middle age, is usually diagnosed after a considerable delay from onset of symptoms. The degree of albumin decrement during an attack correlates with development of rhabdomyolysis. A reduction in the frequency and/or the severity of attacks was seen in nearly three-fourths of patients who were offered empirical therapies. The rate of progression to multiple myeloma appears to be comparable to that of monoclonal gammopathy of undetermined significance. 1 dig(s) dig it bury topic: health comments (0) who dugg this story? Email this link add your comment please login or signup to leave a comment related stories high-dose intravenous immunoglobulins: a promising therapeutic approach for idiopathic systemic capillary leak syndrome submitted by harryport 1 year and 5 months ago the systemic capillary leak syndrome (scls), also known as clarkson’s disease, is a life-threatening disorder of unknown cause. It is characterised by recurrent acute episodes of hypotension, weight.




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